Foundayo weight loss tablets in the UK
A once-daily GLP-1 tablet with no food or water restrictions - with an average of 12.4% body weight lost in clinical trials.
No needles, no timing rules. And Everwell adds the doctor, coach and app that help you reach your goal.
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Clinically proven results
Foundayo was studied in the ATTAIN phase 3 programme - randomised, double-blind, placebo-controlled trials in adults with obesity, or overweight with a weight-related condition1.
Results achieved when combined with a reduced-calorie diet and increased physical activity - the approach supported through the Everwell programme. Based on the ATTAIN phase 3 programme. Results represent estimated outcomes assuming 100% adherence in a clinical trial population. Individual results vary.
The weight you can expect to lose
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Three things medication in the post can't give you.
Weight loss medication works best with proper support. At Everwell, you get comprehensive care designed to maximise your results and help you maintain them long-term.
Access UK-registered doctors, prescribers, and specialists throughout your journey. Get guidance on dosing, side effects management, and treatment optimisation.
Work with dedicated coaches who help you build sustainable habits in nutrition, exercise, and lifestyle. Our patients with coaching support achieve significantly better outcomes.
Meal plans, exercise programmes, educational resources, and a supportive community - all through the app. Discreet delivery, easy subscription management, and the ability to pause or cancel anytime.
Four medications. One right fit.
Injection or tablet, weekly or daily, and how much weight each one helps people lose. Your doctor decides which suits your health profile on your first consultation.
/* Weight loss figures are the average at each medication's highest trial dose alongside diet and exercise, and come from separate clinical trials that cannot be directly compared. Individual results vary. Your doctor decides which medication is clinically appropriate for you. References: a SURMOUNT-1 (tirzepatide 15mg, 72 weeks), b STEP 1 (semaglutide 2.4mg, 68 weeks), c OASIS 4 (oral semaglutide 25mg, 64 weeks), d ATTAIN (orforglipron 17.2mg, 72 weeks). */
What taking it will involve.
Foundayo is swallowed whole once daily, at any time of day, with or without food and with no water restriction.
Your Foundayo treatment plan
Foundayo treatment begins at 0.8 mg once daily and increases through a process called titration, with each step held for at least 30 days. This allows your body to adjust and minimises side effects4.
Not everyone needs the highest dose. The maximum is 17.2 mg once daily, and your maintenance dose depends on how you respond and tolerate treatment. Your Everwell prescriber personalises your schedule based on progress, side effects and health goals.
How to order Foundayo
Get started today
Open your account and complete an online health questionnaire - takes around 5 minutes.
Doctor Consultation
A GMC-registered GP reviews your assessment and discusses your treatment plan.
Medication Delivered
Your Foundayo arrives discreetly with everything you need to start.
Everything you need to know about Foundayo
Written and reviewed by our UK-registered medical team. Pick a topic.
What is Foundayo?
Foundayo is the brand name for orforglipron, a once-daily GLP-1 receptor agonist taken as a tablet. In clinical trials, adults taking the highest dose lost an average of 12.4% of their body weight over 72 weeks1.
Foundayo works by mimicking GLP-1, a natural gut hormone that regulates appetite. This helps you feel fuller for longer, reduces cravings, and supports sustainable weight loss2.
What sets Foundayo apart from other oral GLP-1s is its chemistry. It is a non-peptide small molecule rather than a peptide, so it survives digestion without an absorption enhancer. That means no empty-stomach rule, no water limit, and no waiting before you eat.
The science behind Foundayo
Foundayo works by mimicking GLP-1, a natural hormone that regulates appetite and blood sugar levels in your body2.
How to take Foundayo
What to expect: side effects
Like all medications, Foundayo can cause side effects, though not everyone experiences them. Most are mild and decrease as your body adjusts through the titration schedule.
Common side effects*
The most common side effects are gastrointestinal and typically occur when starting treatment or increasing your dose:
These side effects are usually mild to moderate and tend to improve significantly within a few weeks as your body adjusts. Your Everwell health coach can provide personalised guidance, and our medical team can adjust your treatment plan if side effects persist.
Am I eligible for Foundayo?
Foundayo is a prescription medication for weight management in specific circumstances. Our prescribers assess your eligibility during consultation.
You may be eligible if:
Foundayo may not be suitable if:
During consultation, discuss all current medications, supplements, and your complete medical history with your prescriber.
How does Foundayo compare to other medications?
Choosing the right weight loss medication depends on your individual needs, health profile, and weight loss goals. Mounjaro, Wegovy, Wegovy Pill and Foundayo are compared side by side further up this page.
See the full four-medication comparison table →Why choose Foundayo?
Foundayo suits people who want a GLP-1 without needles and without timing rules. It is the only oral GLP-1 that can be taken at any time of day, with or without food - which for many people is the difference between taking it consistently and not.
Unsure which medication is right for you?
During your consultation, our prescribers will review your medical history, weight loss goals, and personal preferences to recommend the most suitable medication for your situation.
Common questions answered
Is Foundayo available in the UK?▾
Yes. Foundayo (orforglipron) is available on prescription through Everwell as a once-daily GLP-1 tablet for weight management. Your Everwell doctor will decide whether it is clinically appropriate for you during your consultation.
What is Foundayo?▾
Foundayo is the brand name for orforglipron, a once-daily GLP-1 receptor agonist taken as a tablet. Unlike other oral GLP-1 medications it is a non-peptide small molecule, which means it can be taken at any time of day with or without food and without water restrictions.
How much weight can I lose on Foundayo?▾
In a 72-week clinical trial, adults taking the highest dose of Foundayo alongside a reduced-calorie diet and increased physical activity lost an average of 12.4% of their body weight, compared with around 2% on placebo. Individual results vary.
How do I take Foundayo?▾
One tablet once daily, at any time of day, with or without food. There is no need to wait before eating and no water restriction. Most people find it easiest to take it at the same time each day.
What doses does Foundayo come in?▾
Treatment starts at 0.8 mg once daily and increases after at least 30 days to 2.5 mg, then 5.5 mg. Your prescriber may then increase to 9 mg, 14.5 mg or 17.2 mg, each after at least 30 days, based on how you respond and tolerate it. The maximum dose is 17.2 mg once daily.
What are the common side effects?▾
The most commonly reported side effects are gastrointestinal: nausea, constipation, diarrhoea, vomiting, indigestion and abdominal pain. Headache, bloating, fatigue, belching, heartburn, wind and hair loss have also been reported. Most are mild and improve as your body adjusts through the titration schedule.
How can I manage nausea?▾
Nausea is common in the first weeks and after each dose increase. Smaller, lower-fat meals help, as does eating slowly, staying hydrated, and avoiding very rich or greasy food. If it is persistent or severe, speak to your Everwell doctor, who may hold you at your current dose for longer.
What serious side effects should I watch for?▾
Seek medical attention immediately if you experience severe or persistent abdominal pain (possible pancreatitis), yellowing of the skin or eyes, symptoms of a serious allergic reaction such as facial swelling or difficulty breathing, or severe and prolonged vomiting or diarrhoea, which can cause dehydration and kidney problems. These are rare, but act quickly if they occur.
How is Foundayo different from the Wegovy Pill?▾
Both are once-daily GLP-1 tablets, but they work differently. The Wegovy Pill contains oral semaglutide and must be taken on an empty stomach with a small glass of water, waiting 30 minutes before eating. Foundayo contains orforglipron, a non-peptide molecule that can be taken at any time with or without food. The Wegovy Pill has shown greater average weight loss in trials.
Can I take Foundayo with other medications?▾
Foundayo interacts with medicines that affect the CYP3A4 enzyme. The maximum dose is 9 mg daily if you take a strong CYP3A4 inhibitor, and strong CYP3A4 inducers should be avoided. Foundayo is not recommended alongside any other GLP-1 medication. Discuss everything you take with your prescriber.
What if I miss a dose?▾
Take it as soon as you remember, at any time of day. Never take two tablets to make up for a missed one. If you miss seven or more doses in a row, your prescriber will restart your titration at a lower dose to reduce the risk of side effects.
Can I drink alcohol while taking Foundayo?▾
Alcohol is not strictly contraindicated, but it can worsen nausea and dehydration and tends to undermine weight management goals. It is best to minimise alcohol during your programme. Your clinician can advise based on your situation.
Will I regain weight after stopping?▾
Weight regain after stopping any GLP-1 is common, because the appetite-suppressing effect stops too. This is why the habits you build during your Everwell programme matter - your coach will help you plan a long-term strategy well before you come off treatment.
Can I take Foundayo if trying to conceive?▾
No. Foundayo should not be used if you are trying to become pregnant, are pregnant, or are breastfeeding. Women of childbearing age should use effective contraception during treatment. Speak to your Everwell doctor for advice on timing.
Do I need to exercise while taking Foundayo?▾
Yes. Foundayo is licensed for use alongside a reduced-calorie diet and increased physical activity - in trials, that meant a recommended minimum of 150 minutes a week. Exercise improves your results and helps preserve muscle mass during weight loss. Your Everwell health coach will help you build a plan you can sustain.
Ready to start your programme?
Join thousands of people across the UK who are achieving sustainable weight loss with Everwell.
Take the first step today with our quick online assessment. A GMC-registered GP will review your information and help determine if Foundayo is right for you.
Get startedMedical Disclaimer: The information on this page is for educational purposes only and should not replace professional medical advice. Foundayo (orforglipron) is a prescription-only medication. Eligibility and suitability will be determined by a registered healthcare professional during consultation. Results are based on the ATTAIN phase 3 programme and represent estimated outcomes assuming 100% adherence in a clinical trial population. Individual results will vary. Always read the Patient Information Leaflet provided with your medication. Foundayo is a trademark of Eli Lilly and Company. Everwell is an independent prescribing service and is not affiliated with or endorsed by Eli Lilly.
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