Alli weight loss capsules in the UK
You could lose up to 10% of your body weight with clinically proven, non-prescription weight loss capsules.
Capsules alone rarely stick. Everwell adds the doctor, coach and app that make a low-fat diet workable.
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Clinically proven results
Alli has demonstrated effective results in extensive clinical trials when combined with a reduced-calorie, low-fat diet.
Results were achieved when combined with a reduced-calorie diet where no more than 30% of calories came from fat - the approach supported through the Everwell programme.
The weight you can expect to lose
Get more from Alli with Everwell
Three things medication in the post can't give you.
Alli works best when combined with a low-fat diet and lifestyle support. At Everwell, you get comprehensive care designed to maximise your results and help you maintain them long-term.
Access UK-registered doctors, prescribers, and specialists throughout your journey. Get guidance on medication use, side effects management, and treatment optimisation.
Work with dedicated coaches who help you build sustainable habits in nutrition, exercise, and lifestyle. Learn how to manage a low-fat diet effectively to minimise side effects and maximise results.
Low-fat meal plans, exercise programmes, educational resources, and a supportive community - all through the app. Discreet delivery, easy subscription management, and the ability to pause or cancel anytime.
The prescription options, compared.
Alli is the only option on the programme that needs no prescription. If you want a stronger result, these are the prescription medications your doctor can consider on your first consultation.
/* For comparison, Alli (orlistat 60mg) gives up to 10% weight loss and needs no prescription. Weight loss figures are the average at each medication's highest trial dose alongside diet and exercise, and come from separate clinical trials that cannot be directly compared. Individual results vary. Your doctor decides which medication is clinically appropriate for you. References: a SURMOUNT-1 (tirzepatide 15mg, 72 weeks), b STEP 1 (semaglutide 2.4mg, 68 weeks), c OASIS 4 (oral semaglutide 25mg, 64 weeks), d ATTAIN (orforglipron 17.2mg, 72 weeks). */
This is what arrives.
Your Alli delivery includes a 4-week supply (84 capsules) with complete usage instructions. Our team is available through the Everwell app if you have questions.
Your Alli treatment plan
Alli is taken three times daily with meals that contain fat. Each capsule is 60mg of orlistat. If you eat a meal with no fat, you can skip that dose2.
For best results, your diet should contain no more than 30% of calories from fat, evenly distributed across three main meals. This helps minimise side effects whilst maximising weight loss2. You should also take a daily multivitamin containing fat-soluble vitamins (A, D, E, K) at bedtime, at least 2 hours after your last Alli dose, as the medication may reduce vitamin absorption2.
How to order Alli
Get started today
Open your account and complete an online health questionnaire
Team review
Our team reviews your assessment to ensure Alli is suitable for you.
Medication Delivered
Your Alli arrives discreetly with everything you need to start.
Everything you need to know about Alli
Written and reviewed by our UK-registered medical team. Pick a topic.
What is Alli?
Alli (orlistat 60mg) is a clinically proven weight loss capsule available without prescription in the UK. Clinical trials show patients lose an average of 10% of their body weight when combined with a reduced-calorie diet1.
Unlike appetite suppressants, Alli works in your digestive system to block approximately 25% of the fat you eat from being absorbed2. The unabsorbed fat passes naturally through your body, reducing your calorie intake.
Taken three times daily with meals, Alli is ideal for people who prefer a non-injection option or want to start their weight loss journey without prescription medication.
The science behind Alli
Alli works differently to prescription weight loss medications. Instead of affecting your brain or hormones, it acts in your digestive system2.
How to use Alli
What to expect: side effects
Like all medications, Alli can cause side effects, though not everyone experiences them. Most side effects are gastrointestinal and related to fat consumption2.
Common side effects*
The most common side effects occur when eating foods high in fat and typically include2:
These side effects are more likely if you consume more than 30% of your daily calories from fat. They can be minimised by following a low-fat diet as recommended2. Your Everwell health coach can provide personalised guidance on managing a low-fat diet effectively.
Am I eligible for Alli?
Alli is available without prescription for adults who meet specific weight criteria. Our team can help determine if it's the right choice for you.
You may be eligible if:
Alli may not be suitable if:
During consultation, discuss all current medications, supplements, and your complete medical history with your prescriber.
How does Alli compare to other medications?
Choosing the right weight loss medication depends on your individual needs, health profile, and weight loss goals. Mounjaro, Wegovy, Wegovy Pill and Foundayo are compared side by side further up this page.
See the full four-medication comparison table →Why choose Alli?
Alli is ideal if you prefer to avoid injections, want to start without a prescription, or have a lower BMI. It's a proven, accessible option that works well for people committed to following a low-fat diet.
Unsure which medication is right for you?
During your consultation, our prescribers will review your medical history, weight loss goals, and personal preferences to recommend the most suitable medication for your situation.
Common questions answered
How quickly will I see results with Alli?▾
Weight loss with Alli is gradual. Most people see results within 2-4 weeks when following a reduced-calorie, low-fat diet. Clinical trials showed average weight loss of 10.2% over one year.
What are the common side effects?▾
The most common side effects are gastrointestinal and related to fat consumption: oily spotting, flatulence with discharge, urgent bowel movements, fatty or oily stools, and abdominal discomfort. These are more likely if you eat high-fat meals.
How can I minimise side effects?▾
Follow a low-fat diet where no more than 30% of calories come from fat. Spread your fat intake evenly across three meals. Start with lower-fat meals when beginning Alli to allow your body to adjust.
What serious side effects should I watch for?▾
While rare, contact your healthcare provider immediately for: severe stomach pain, signs of liver problems (yellowing skin/eyes), rectal bleeding, severe allergic reactions, or signs of pancreatitis. Stop taking Alli and seek medical attention.
Can I drink alcohol while taking Alli?▾
Yes, Alli doesn't interact with alcohol. However, alcoholic drinks contain calories that can hinder weight loss, and some drinks are high in fat (like cream liqueurs). Drink in moderation.
How long can I take Alli?▾
Alli should not be taken for more than 6 months continuously without medical review. If you haven't lost weight after 12 weeks, consult your healthcare provider - you may need to stop taking Alli or try a different approach.
What if I miss a dose?▾
If you miss a dose, don't double up at your next meal. You simply lose the benefit of Alli for that meal. Continue with your regular schedule.
Can I use Alli with type 2 diabetes?▾
Alli can be used by people with type 2 diabetes, but your diabetes medication may need adjustment as you lose weight. Inform your healthcare provider and monitor your blood sugar levels carefully.
Will I regain weight after stopping?▾
Weight regain is possible without maintaining healthy habits. The Everwell programme helps you build sustainable lifestyle changes, particularly low-fat eating patterns, to support long-term weight maintenance.
Is Alli available through the NHS?▾
Alli is not available through the NHS as it's an over-the-counter medication. However, it's more affordable than prescription weight loss medications and doesn't require a prescription.
Do I need to exercise?▾
While Alli supports weight loss by blocking fat absorption, exercise enhances results, preserves muscle mass, boosts metabolism, and improves overall health. Even moderate activity makes a significant difference.
Can I take Alli if trying to conceive?▾
No. Do not take Alli if you're pregnant, planning pregnancy, or breastfeeding. Discuss weight loss plans with your healthcare provider if you're trying to conceive.
Why do I need to take vitamins with Alli?▾
Alli may reduce absorption of fat-soluble vitamins (A, D, E, K). Taking a daily multivitamin ensures you maintain adequate vitamin levels. Take it at bedtime or at least 2 hours away from your Alli doses.
Can I take Alli with other medications?▾
Alli can interact with certain medications including warfarin, ciclosporin, diabetes medications, thyroid medications, and anti-epileptic drugs. Always inform your healthcare provider about all medications you take.
What's the difference between Alli and prescription orlistat?▾
Alli contains 60mg orlistat and is available over-the-counter. Prescription orlistat (Xenical) contains 120mg - double the strength - and requires a prescription. Alli is suitable for people with lower BMI or those preferring to start with a lower dose.
How is Alli different from GLP-1 medications?▾
Alli works in your digestive system to block fat absorption, whilst GLP-1 medications (like Wegovy and Mounjaro) work on your brain and hormones to reduce appetite. Alli is taken daily as a capsule; GLP-1s are weekly injections. GLP-1s typically produce greater weight loss but require prescriptions.
Ready to start your programme?
Join thousands of people across the UK who are achieving sustainable weight loss with Alli.
Take the first step today with our quick online assessment. Our team will review your information and help determine if Alli is right for you.
Get startedMedical Disclaimer: The information on this page is for educational purposes only and should not replace professional medical advice. Alli is an over-the-counter medication available without prescription. Suitability will be reviewed by a registered healthcare professional before supply.
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